Testing mode of inheritance of a candidate mutation at a quantitative trait locus

Here is presented an approach to testing whether the effect of a candidate gene on a quantitative trait is dominant and for testing whether the effect is recessive, The approach uses parental genotype information in nuclear f amilies to adjust for bias due to population admixture, The approach is app licable regardless of the nature of the sampling, The results of an applica tion of the methods to a candidate mutation for diabetic nephropathy are us ed for illustration. Copyright (C) 2000 S. Karger AG, Basel.