Antigen processing and presentation by intestinal epithelial cells - polarity and complexity

Authors
Hershberg, RM Mayer, LF
Citation
Rm. Hershberg et Lf. Mayer, Antigen processing and presentation by intestinal epithelial cells - polarity and complexity, IMMUNOL TOD, 21(3), 2000, pp. 123-128
Citations number
54
Categorie Soggetti
Immunology
Journal title
IMMUNOLOGY TODAY
ISSN journal
01675699 → ACNP
Volume
21
Issue
3
Year of publication
2000
Pages
123 - 128
Database
ISI
SICI code
0167-5699(200003)21:3<123:APAPBI>2.0.ZU;2-8
Abstract
The mechanisms by which gut-associated lymphoid tissue (GALT) maintains a b alance between oral tolerance and active immune response in the face of exp osure to high antigen concentrations remains a central question in mucosal immunity. Here, Robert Hershberg ann colleagues discuss the evidence that h uman intestinal epithelial cells function as antigen-presenting cells (APCs ) capable of regulating T-cell responses in the intestinal mucosa.