Regulation of T-cell responses by CNS antigen-presenting cells: different roles for microglia and astrocytes

Analysis of the mechanisms underlying CNS immune surveillance and immunopat hology have provided new insights into the intracerebral regulation of immu ne responses. Here, Francesca Aloisi, Francesco Ria and Luciano Adorini rev iew, the role of CNS antigen presenting cells and focus on the control of T h1 and Th2 responses by microglia and astrocytes.