Ln. Ma et al., Endothelial dysfunction associated with left ventricular diastolic dysfunction in patients with coronary heart disease, INT J CARD, 72(3), 2000, pp. 275-279
Citations number
20
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Objective: We sought to assess the correlation between endothelial vasodila
tion and left ventricular diastolic function. Background: Previous studies
have demonstrated that similar neurohumoral factors are involved in myocard
ial and vascular endothelial impairment. The degree of endothelial dysfunct
ion is related to the clinical severity of the heart failure. However, it i
s not clear whether endothelial dysfunction develops with the progression o
f left ventricular diastolic dysfunction. We hypothesize that the endotheli
al dysfunction is associated with left ventricular diastolic dysfunction. M
ethods: Using high-resolution ultrasound, we measured the dilator response
of the brachial artery to hyperemia (endothelium-dependent vasodilation) an
d to 0.5 mg nitroglycerin (endothelium-independent vasodilation), and measu
red peak velocities of the early wave (Evmax) and the atrial wave (Avmax) i
n 40 coronary heart disease (CHD) patients and 20 normal subjects, We analy
zed the relationship between the Evmax/Avmax ratio and endothelium-dependen
t vasodilation. Results: The results showed that endothelium-dependent and
endothelium-independent vasodilation as well as the Evmax/Avmax ratio were
lower in the CHD group than those in the control group (4.29%+/-1.42%, 17.5
8%+/-2.99%, 0.81+/-0.24 vs. 9.62%+/-2.34%, 24.18%+/-3.15%, 1.07+/-0.29, res
pectively, P<0.01). The Evmax/Avmax ratio was related to endothelium-depend
ent vasodilation (r=0.45, P<0.01). Conclusions: Our results showed that the
development of endothelial dysfunction was associated with the progression
of myocardial diastolic dysfunction, which suggests that the same mechanis
ms may be involved in the impairment of endothelium and myocardium, (C) 200
0 Elsevier Science Ireland Ltd. All rights reserved.