G. Dowe et al., Symptomatic and asymptomatic chlamydial non-gonococcal urethritis in Jamaica: the potential for HIV transmission, INT J STD A, 11(3), 2000, pp. 187-190
To determine the contribution of Chlamydia trachomatis to nongonococcal ure
thritis (NGU) in men attending sexually transmitted disease (STD) clinics i
n Jamaica we studied men with NGU (n = 339), and control groups including a
symptomatic men who were STD contacts (n = 61), asymptomatic men who were n
ot STD contacts (n = 32) and men with gonococcal urethritis (GU) (n = 61).
Urethral specimens were examined for C. trachomatis and Neisseria gonorrhoe
ae. Serological tests for syphilis (STS) and HIV-1 infection were also perf
ormed. C. trachomatis accounted for 63% of cases of NGU but high prevalence
s were also found in asymptomatic STD contacts (59%), asymptomatic STD non-
contacts (78%) and men with GU (48%). The prevalence of C. trachomatis in m
en with GU differed significantly from that in men with NGU and asymptomati
c STD non-contacts (P < 0.05). C. trachomatis infection in men with NGU was
associated with multiple sex partners (71% vs 58%; chi(2) = 4.78; odds rat
io (OR) = 1.76; P < 0.05) and previous history of gonococcal infection (83%
vs 42%; chi(2) = 59.8; OR = 6.8; P < 0.0001). Concomitant infection with H
IV-1 occurred in 5.2% of cases of NGU and 50% and 90%, respectively, of the
HIV-positive men had chlamydia or reactive STS. As a cost effective strate
gy in the control of STD and HN we recommend presumptive treatment for C. t
rachomatis in men seeking STD treatment in Jamaica.