D. Barron et al., Prediction of electrophoretic mobilities in non-aqueous capillary electrophoresis - Optimal separation of quinolones in acetonitrile-water media, J CHROMAT A, 871(1-2), 2000, pp. 367-380
A model of electrophoretic behaviour is used to predict the optimum conditi
ons for the separation of a series of quinolones zwitterionic substances in
mixtures of acetonitrile-water up to 30% (w/w) of acetonitrile. The effect
of pH, pK(a), the electrophoretic mobility of protonated and anionic speci
es, and activity coefficients on the electrophoretic behaviour of quinolone
s is considered. The model proposed allows the resolution between substance
s in acetonitrile-water mixtures to be predicted from a few experimental da
ta and thus permits one to obtain the best experimental conditions for sepa
ration methodologies. (C) 2000 Elsevier Science B.V. All rights reserved.