Sa. Brown et al., Effects of dietary polyunsaturated fatty acid supplementation in early renal insufficiency in dogs, J LA CL MED, 135(3), 2000, pp. 275-286
Citations number
73
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research General Topics
Dietary supplementation with polyunsaturated fatty acids (PUFAs) alters the
course of experimental kidney disease in dogs. In particular, supplementat
ion with omega-6 PUFAs hastens the decline of kidney function, and omega-3
PUFAs are renoprotective. We investigated the early stages of renal insuffi
ciency to determine whether PUFA supplementation altered the magnitude of h
ypercholesterolemia or glomerular hemodynamics. Two months after 11/12 neph
rectomy, dogs were randomly divided into three groups of 6 animals each. Ea
ch group of dogs was then fed a low-fat basal diet supplemented with one of
three sources of lipid to achieve a final concentration of 15% added fat.
Fat sources were rich in omega-3 PUFAs (menhaden fish oil, group FO), omega
-6 PUFAs (safflower oil, group SO), or saturated fatty acids (beef tallow,
group C), Early in renal insufficiency, before significant kidney damage, g
roup FO had a lower (P < .05) serum cholesterol concentration and tended to
have a lower urinary prostaglandin E2 (PGE2) and thromboxane A2 (TxA2) exc
retion than group C. In contrast, group SO had a higher mean glomerular cap
illary pressure (P < .05) and more glomerular enlargement (P < .05) and ten
ded to have higher eicosanoid excretion rates than group C, These differenc
es in lipid metabolism, glomerular hypertension and hypertrophy, and urinar
y eicosanoid metabolism could explain, in part, the beneficial effects of o
mega-3 PUFAs and the detrimental effects of omega-6 PUFAs when administered
on a long-term basis in this model of renal insufficiency.