FREQUENCY-DOMAIN TECHNIQUES ENHANCE OPTICAL MAMMOGRAPHY - INITIAL CLINICAL-RESULTS

We present a novel approach to optical mammography and initial clinica l results. We have designed and developed a frequency-domain (110-MHz) optical scanner that performs a transillumination raster scan of the female breast in approximately 3 min, The probing light is a dual-wave length (690 and 810 nm, 10-mW average power), 2-mm-diameter laser beam , and the detection optical fiber is 5 mm in diameter. The ac amplitud e and phase data are processed with use of an algorithm that performs edge effect corrections, thereby enhancing image contrast. This contra st enhancement results in a greater tumor detectability compared with simple light intensity images, The optical mammograms are displayed on a computer screen in real time, We present x-ray and optical mammogra ms from two patients with breast tumors. Our initial clinical results show that the frequency-domain scanner, even at the present stage of d evelopment, has the potential to be a useful tool in mammography.