Involvement of OSP/Claudin-11 in oligodendrocyte membrane interactions: Role in biology and disease

Authors
Bronstein, JM Tiwari-Woodruff, S Buznikov, AG Stevens, DB
Citation
Jm. Bronstein et al., Involvement of OSP/Claudin-11 in oligodendrocyte membrane interactions: Role in biology and disease, J NEUROSC R, 59(6), 2000, pp. 706-711
Citations number
59
Categorie Soggetti
Neurosciences & Behavoir
Journal title
JOURNAL OF NEUROSCIENCE RESEARCH
ISSN journal
03604012 → ACNP
Volume
59
Issue
6
Year of publication
2000
Pages
706 - 711
Database
ISI
SICI code
0360-4012(20000315)59:6<706:IOOIOM>2.0.ZU;2-1
Abstract
Oligodendrocyte-specific protein (OSP/claudin-11) is a four transmembrane p rotein concentrated in central nervous system myelin. Recent evidence has e merged suggesting that OSP/claudin-11 is involved in membrane interactions at tight junctions and with the extracellular matrix. OSP/claudin-11 seems to modulate proliferation and migration of oligodendrocytes presumably thro ugh these interactions. Furthermore, evidence is presented implicating OSP/ claudin-11 as an autoantigen in the development of autoimmune demyelinating disease. J. Neurosci. Res. 59:706-711, 2000. (C) 2000 Wiley-Liss, Inc.