C. Neville et al., Learning from discordance in patient and physician global assessments of systemic lupus erythematosus disease activity, J RHEUMATOL, 27(3), 2000, pp. 675-679
Objective. Differences have been described between patient and physician as
sessments of well being in several chronic illnesses, and these differences
may affect outcome. Disagreement may lead to dissatisfaction and to behavi
ors with dangerous consequences. We describe and identify predictors of pat
ient-physician differences on ratings of disease activity in systemic lupus
erythematosus (SLE).
Methods. Data collected on 154 patients included age, education, disease du
ration, and patient and physician global assessments of lupus activity on a
10 cm visual analog scale (VAS), the Health Assessment Questionnaire (HAQ)
, the Medical Outcome Study Short-Form 36 (SF-36), the Systemic Lupus Disea
se Activity Index (SLEDAI), the Systemic Lupus Activity Measure (SLAM-R), a
nd the Systemic Lupus International Collaborating Clinics/American College
of Rheumatology Damage Index (SDI). Multiple linear regression models were
performed using patient VAS scores, physician VAS scores, and patient minus
physician VAS scores as the dependent variables, and age, disease duration
, selected SF-36 and SLAM-R subscales, and SDI as independent variables.
Results. Patients were 90% female and 80% Caucasian, with a mean education
of 13 +/- 2.8 years and a mean age of 43.1 +/- 13.6 years. The overall mean
disease duration was 10.5 +/- 7.8 years. Physicians overscored patients by
2.5 cm in 6% of the cases and patients overscored physicians in 16% of the
cases. The best multivariate model to predict overall differences included
SF-36 mental health and SLAM-R kidney scores.
Conclusion. Patient-physician differences may result from a divergence in f
ocus. Patients score lupus activity based on their psychological status, wh
ile physicians rely more heavily on the physical effect of the disease.