Dermal toxicity of linear alkylbenzene sulfonate and quinalphos in guinea rigs

Guinea pigs were treated topically at dosage levels of 2.5 mg/kg and 5.0 mg /kg with linear alkylbenzene sulfonate and quinalphos alone and in combinat ion daily for 30 days. In general, the activities of some enzymes, amino ni trogen, glutathione, lipid peroxidation, and histamine showed increases in skin, liver, and kidney. The animals exposed to high doses showed erythema, edema, and hair loss. The treated skin showed hyperkeratinization and infi ltration of mononuclear cells, the liver showed hypertrophic hepatocytes, w hile the kidney showed tubular necrosis and atrophy of the glomerular capsu les. The biochemical parameters and histopathological changes were found to be dose dependent. The study suggests that workers and/or populations expo sed simultaneously to the two chemicals are more prone to dermal toxicity.