Antiischemic and hemodynamic effects, safety of long acting beta(1)-adrenoblocker bisoprolol in patients with stable angina after myocardial infarction

Aim. To assess antiischemic, hemodynamic effects, and safety of bisoprolol in patients with stable angina pectoris after myocardial infarction. Materi al. 24 patients (mean age 53,8+/-3,5 years) with stable class II-III effort angina and history of myocardial infarction. Methods. EC monitoring, echoc ardiography, paired bicycle exercise testing and polarographic assessment o f tissue transcapillary O-2 exchange. Bisoprolol (2,5, 5,0 or 10 mg/day) wa s given once daily. Results. Antianginal efficacy was good in 91,7% of case s: frequency and severity of angina decreased by 40,8%, daily requirements in nitroglycerine pills - by 65,2%, tolerance to physical exercise rose by 35,7%. In patients with hypertension bisoprolol exerted obvious hypotensive action. Side effects registered in 5 patients (19%) were presented as sinu s bradycardia (down to 40 bpm). Conclusion. Bisoprolol is an effective and safe antianginal drug.