Antiischemic and hemodynamic effects, safety of long acting beta(1)-adrenoblocker bisoprolol in patients with stable angina after myocardial infarction
At. Teplyakov et al., Antiischemic and hemodynamic effects, safety of long acting beta(1)-adrenoblocker bisoprolol in patients with stable angina after myocardial infarction, KARDIOLOGIY, 40(2), 2000, pp. 17-20
Aim. To assess antiischemic, hemodynamic effects, and safety of bisoprolol
in patients with stable angina pectoris after myocardial infarction. Materi
al. 24 patients (mean age 53,8+/-3,5 years) with stable class II-III effort
angina and history of myocardial infarction. Methods. EC monitoring, echoc
ardiography, paired bicycle exercise testing and polarographic assessment o
f tissue transcapillary O-2 exchange. Bisoprolol (2,5, 5,0 or 10 mg/day) wa
s given once daily. Results. Antianginal efficacy was good in 91,7% of case
s: frequency and severity of angina decreased by 40,8%, daily requirements
in nitroglycerine pills - by 65,2%, tolerance to physical exercise rose by
35,7%. In patients with hypertension bisoprolol exerted obvious hypotensive
action. Side effects registered in 5 patients (19%) were presented as sinu
s bradycardia (down to 40 bpm). Conclusion. Bisoprolol is an effective and
safe antianginal drug.