Sample size prediction for ophthalmologic studies

An essential aspect in the cooperation of clinic and biometry consists in d esigning of studies, e.g. during the preparation of grant applications or f or review by official drGg surveillance institutions. A central aspect in s tudy planning is the design-adequate and well-documented prediction of samp le size, which should be recommended for any intended study. Based on sever al examples for sample size planning in study designs, which are of common relevance for ophthalmology, guidelines are derived to enable clinical rese archers to perform sample size planning on their own. The latter can be bas ed on the various available software packages for sample size prediction.