In this retrospective cohort analysis of all adults who were members of Kai
ser Permanente, Northern California, between July 1995 and June 1996 (N = 2
,076,303), the authors estimated the prevalence, average annual costs per p
erson, and percentage of total direct medical expenditures attributable to
each of 25 chronic and acute conditions. Ordinary least squares regression
was used to adjust for age, gender, and comorbidities. The costs attributab
le to the 25 conditions accounted for 78 percent of the health maintenance
organization's total direct medical expense for this age-group. Injury acco
unted for a higher proportion (11.5 percent) of expenditures than any other
single condition. Three cardiovascular conditions-ischemic heart disease,
hypertension, and congestive heart failure-together accounted for 17 percen
t of direct medical expense and separately accounted for 6.8 percent, 5.7 p
ercent, and 4.0 percent, respectively. Renal failure ($22,636), colorectal
cancer ($10,506), pneumonia ($9,499), and lung cancer ($8,612) were the mos
t expensive conditions per person per year.