Fragile X (fmr1) mRNA expression is differentially regulated in two adult models of activity-dependent gene expression

Authors
Valentine, G Chakravarty, S Sarvey, J Bramham, C Herkenham, M
Citation
G. Valentine et al., Fragile X (fmr1) mRNA expression is differentially regulated in two adult models of activity-dependent gene expression, MOL BRAIN R, 75(2), 2000, pp. 337-341
Citations number
32
Categorie Soggetti
Neurosciences & Behavoir
Journal title
MOLECULAR BRAIN RESEARCH
ISSN journal
0169328X → ACNP
Volume
75
Issue
2
Year of publication
2000
Pages
337 - 341
Database
ISI
SICI code
0169-328X(20000222)75:2<337:FX(MEI>2.0.ZU;2-L
Abstract
We sought to determine whether the fragile X mental retardation gene fmr1 i s regulated in long-term potentiation (LTP) and electroconvulsive shock (EC S). in situ hybridization of fmr1 mRNA in hippocampus of rats given LTP in vivo showed no change in fmr1 mRNA levels relative to control. However, ECS induced a selective increase in fmr1 mRNA expression in the dentate gyrus (DG) granule cell layer at 6 h post-ECS. The ECS paradigm may unmask releva nt activity-dependent regulatory mechanisms that modulate fmr1 gene transcr iption in vivo. (C) 2000 Elsevier Science B.V. All rights reserved.