Chronic inflammatory demyelinating polyneuropathy after treatment with interferon-alpha

Treatment with interferon-alpha (IFN-alpha) has been associated with the oc currence of a number of autoimmune disorders. We report a case of chronic i nflammatory demyelinating polyneuropathy (CIDP) occurring in a patient with a chronic viral hepatitis C infection who received a novel, long-acting fo rm of IFN-alpha. After withdrawal of the interferon treatment, this patient responded to a single extended course of plasma exchange that resulted in a complete clinical remission of symptoms without relapse. (C) 2000 John Wi ley & Sons, Inc. Muscle Nerve 23: 433-435, 2000.