Synthesis of the C1-C13 fragment of leucascandrolide A

Authors
Crimmins, MT Carroll, CA King, BW
Citation
Mt. Crimmins et al., Synthesis of the C1-C13 fragment of leucascandrolide A, ORG LETT, 2(5), 2000, pp. 597-599
Citations number
14
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
2
Issue
5
Year of publication
2000
Pages
597 - 599
Database
ISI
SICI code
1523-7060(20000309)2:5<597:SOTCFO>2.0.ZU;2-H
Abstract
[GRAPHICS] The synthesis of the C1-C13 fragment 3 of leucascandrolide A has been compl eted utilizing a stereoselective and regioselective reductive cleavage of a highly functionalized spiroketal to incorporate the cis-2,6-disubstituted tetrahydropyan. The spiroketal was constructed by addition of a lithiated, pyrone 5 to aldehyde 6.