Citation
T. Ohkuma et al., Selective hydrogenation of benzophenones to benzhydrols. Asymmetric synthesis of unsymmetrical diarylmethanols, ORG LETT, 2(5), 2000, pp. 659-662
Citations number
49
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060
→ ACNP
Volume
2
Issue
5
Year of publication
2000
Pages
659 - 662
Database
ISI
SICI code
1523-7060(20000309)2:5<659:SHOBTB>2.0.ZU;2-6
Abstract
[GRAPHICS]
trans-RuCl2[P(C6H4-4-CH3)(3)](2)(NH2CH2CH2NH2) acts as a highly effective p
recatalyst for the hydrogenation of a variety of benzophenone derivatives t
o benzhydrols that proceeds smoothly at 8 atm and 23-35 degrees C in 2-prop
anol containing t-C4H9OK with a substrate/catalyst ratio of 2000-20000. Use
of a BINAP/chiral diamine Ru complex effects asymmetric hydrogenation of v
arious ortho-substituted benzophenones and benzoylferrocene to chiral diary
lmethanols with consistently high ee.