A method for the asymmetric hydrosilylation of N-aryl imines

Authors
Hansen, MC Buchwald, SL
Citation
Mc. Hansen et Sl. Buchwald, A method for the asymmetric hydrosilylation of N-aryl imines, ORG LETT, 2(5), 2000, pp. 713-715
Citations number
17
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
2
Issue
5
Year of publication
2000
Pages
713 - 715
Database
ISI
SICI code
1523-7060(20000309)2:5<713:AMFTAH>2.0.ZU;2-J
Abstract
[GRAPHICS] The asymmetric reduction of N-aryl imines to yield chiral amines with enant iomeric excesses above 90% was achieved. Ethylenebis(eta(5)-tetrahydroinden yl)titanium difluoride ((EBTHI)TiF2, 1) was employed as the precatalyst wit h polymethylhydrosiloxane (PMHS) as the stoichiometric reducing agent. A va riety of N-aryl imines derived from nonaromatic ketones were reduced with h igh ee.