The highly protective effect of newborn circumcision against invasive penile cancer

Objective. We determined the relation between newborn circumcision and both invasive penile cancer (IPC) and carcinoma in situ (CIS) among adult male members of a large health maintenance organization. Subjects and Methods. Circumcision status was ascertained by a combination of pathology reports, medical record review, and questionnaires for 213 adu lt male members of a large prepaid health plan who were diagnosed with IPC or CIS. Results. Of 89 men with IPC whose circumcision status was known, 2 (2.3%) h ad been circumcised as newborns, and 87 were not circumcised. Of 118 men wi th CIS whose circumcision status was known, 16 (15.7%) had been circumcised as newborns. Conclusions. Our results confirm the highly protective effect of newborn ci rcumcision against IPC and the less protective effect against CIS.