Neurotransmitter dysfunction in patients with borderline personality disorder

Authors
Gurvits, IG Koenigsberg, HW Siever, LJ
Citation
Ig. Gurvits et al., Neurotransmitter dysfunction in patients with borderline personality disorder, PSYCH CL N, 23(1), 2000, pp. 27
Citations number
89
Categorie Soggetti
Psychiatry
Journal title
PSYCHIATRIC CLINICS OF NORTH AMERICA
ISSN journal
0193953X → ACNP
Volume
23
Issue
1
Year of publication
2000
Database
ISI
SICI code
0193-953X(200003)23:1<27:NDIPWB>2.0.ZU;2-K
Abstract
Neurotransmitter system dysfunction may contribute to the borderline person ality disorder traits of impulsive aggression and affective instability. Th is article reviews evidence from neurochemical assays, receptor-density stu dies, neuroendocrine-challenge paradigms, functional neuroimaging studies, and candidate-gene research, which converge to identify particular neurotra nsmitter systems that seem to be dysregulated in patients with borderline p ersonality disorder.