Acylation of diethyl phosphonoacetic acid via the MgCl2/Et3N system: A practical synthesis of beta-keto phosphonates

Authors
Corbel, B L'Hostis-Kervella, I Haelters, JP
Citation
B. Corbel et al., Acylation of diethyl phosphonoacetic acid via the MgCl2/Et3N system: A practical synthesis of beta-keto phosphonates, SYN COMMUN, 30(4), 2000, pp. 609-618
Citations number
64
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNTHETIC COMMUNICATIONS
ISSN journal
00397911 → ACNP
Volume
30
Issue
4
Year of publication
2000
Pages
609 - 618
Database
ISI
SICI code
0039-7911(2000)30:4<609:AODPAV>2.0.ZU;2-V
Abstract
A one pot simple procedure for the synthesis of beta-keto phosphonates has been developed using the MgCl2/Et3N base system to generate the magnesium e nolate of diethyl phosphonoacetic acid. This intermediate reacts with acid chlorides or imidazolides to give, after workup, the title compounds in goo d yields.