A continuous Michael and aldol coupling of alpha,beta-enones catalyzed by iridium complexes

Authors
Matsuda, I Makino, T Hasegawa, Y Itoh, K
Citation
I. Matsuda et al., A continuous Michael and aldol coupling of alpha,beta-enones catalyzed by iridium complexes, TETRAHEDR L, 41(9), 2000, pp. 1409-1412
Citations number
15
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
9
Year of publication
2000
Pages
1409 - 1412
Database
ISI
SICI code
0040-4039(20000226)41:9<1409:ACMAAC>2.0.ZU;2-P
Abstract
Ir[(COD)(PPh3)(2)]OTf activated by H-2 molecule catalyzes Michael-type coup ling of alpha,beta-enones with enoxysilanes to give 1,5-dicarbonyl compound s after the subsequent protodesilylation. An identical catalyst system make s it possible to attain a continuous Michael and aldol modification toward alpha,beta-enones in a one-pot operation. (C) 2000 Elsevier Science Ltd. Al l rights reserved.