The synthesis of substituted pyridylpyrimidine fungicides using palladium-catalysed cross-coupling reactions

Authors
Hargreaves, SL Pilkington, BL Russell, SE Worthington, PA
Citation
Sl. Hargreaves et al., The synthesis of substituted pyridylpyrimidine fungicides using palladium-catalysed cross-coupling reactions, TETRAHEDR L, 41(10), 2000, pp. 1653-1656
Citations number
14
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
10
Year of publication
2000
Pages
1653 - 1656
Database
ISI
SICI code
0040-4039(20000304)41:10<1653:TSOSPF>2.0.ZU;2-7
Abstract
Various substituted phenyl, pyridyl and benzyl zinc chlorides have been gen erated from the corresponding lithium or magnesium organometallic reagents. These have been cross-coupled with 2-(6-bromo-2-pyridyl)pyrimidines in the presence of tetrakis(triphenylphosphine)palladium(0) to produce a series o f substituted pyridylpyrimidine fungicides in 32-99% yields. (C) 2000 Elsev ier Science Ltd. All rights reserved.