Mechanism of action studies of cytotoxic marine alkaloids: ascididemin exhibits thiol-dependent oxidative DNA cleavage

Authors
Matsumoto, SS Sidford, MH Holden, JA Barrows, LR Copp, BR
Citation
Ss. Matsumoto et al., Mechanism of action studies of cytotoxic marine alkaloids: ascididemin exhibits thiol-dependent oxidative DNA cleavage, TETRAHEDR L, 41(10), 2000, pp. 1667-1670
Citations number
8
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
10
Year of publication
2000
Pages
1667 - 1670
Database
ISI
SICI code
0040-4039(20000304)41:10<1667:MOASOC>2.0.ZU;2-6
Abstract
The cytotoxic marine alkaloid ascididemin has been shown to be a thiol-depe ndent DNA cleaving agent. Previous mechanisms of action studies have conclu ded that DNA and/or the DNA processing enzyme topoisomerase II were the cel lular targets for the alkaloid - this is the first direct evidence that a p yridoacridone alkaloid can cause DNA cleavage under physiological condition s. (C) 2000 Elsevier Science Ltd. All rights reserved.