Large de novo renal cell carcinoma in a 10-year-old transplanted kidney - Successful organ-preserving therapy

Citation
M. Siebels et al., Large de novo renal cell carcinoma in a 10-year-old transplanted kidney - Successful organ-preserving therapy, TRANSPLANT, 69(4), 2000, pp. 677-679
Citations number
7
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
TRANSPLANTATION
ISSN journal
00411337 → ACNP
Volume
69
Issue
4
Year of publication
2000
Pages
677 - 679
Database
ISI
SICI code
0041-1337(20000227)69:4<677:LDNRCC>2.0.ZU;2-O
Abstract
Background. A recent review of the Cincinnati Transplant Tumor Registry rec orded 24 de novo renal cell carcinomas developing in renal allografts. Howe ver, late development of these tumors after transplantation is very rare. O nly four reports exist regarding conservative surgery on kidney transplant tumors. Methods. This is a report on a case of a large 6-cm de novo renal cell carc inoma in a 10-year-old transplanted kidney. Optimal therapy by transplant n ephrectomy or tumor enucleation was discussed. Results. Partial resections or enucleations of renal cell carcinoma are sti ll less than ideal in carcinomas larger than 3 cm considering the higher ri sk of local recurrence. But the recipient in this case had done so well and had had such a high quality of life after transplantation that partial nep hrectomy as therapy of choice was selected. Now the patient is 2 years tumo r free. Conclusion. The case report demonstrates that in certain select cases of la rge tumors, organ-preserving surgery could be an alternative approach in co mbining complete tumor removal with preservation of graft function.