REGIOSPECIFIC SYNTHESIS OF 15-(4-[I-123]IODOPHENYL)PENTADECANOIC ACIDIPPA VIA METHYL 15-(4-TRIMETHYLSTANNYLPHENYL)PENTADECANOATE

Authors
CULBERT PA LU JM ADAM MJ
Citation
Pa. Culbert et al., REGIOSPECIFIC SYNTHESIS OF 15-(4-[I-123]IODOPHENYL)PENTADECANOIC ACIDIPPA VIA METHYL 15-(4-TRIMETHYLSTANNYLPHENYL)PENTADECANOATE, Applied radiation and isotopes, 48(6), 1997, pp. 745-747
Citations number
9
Categorie Soggetti
Nuclear Sciences & Tecnology","Radiology,Nuclear Medicine & Medical Imaging","Chemistry Inorganic & Nuclear
Journal title
Applied radiation and isotopes
ISSN journal
09698043 → ACNP
Volume
48
Issue
6
Year of publication
1997
Pages
745 - 747
Database
ISI
SICI code
0969-8043(1997)48:6<745:RSO1A>2.0.ZU;2-U
Abstract
The synthesis of methyl 15-(4-trimethylstannylphenyl)pentadecanoate (p -SnPPA), a precursor for the regiospecific production of 15-(4-[I-123] -iodophenyl)pentadecanoic acid, is described. The stannylated precurso r is synthesized in six steps from 4-bromophenylacetylene in an overal l yield of 16%. p-SnPPA reacts with N.C.A. [I-123]NaI in the presence of peracetic acid to yield IPPA in 62% radiochemical yield following h ydrolysis. (C) 1997 Elsevier Science Ltd.