Cox-2 expression in retinoblastoma

PURPOSE: Cox-2, a prostaglandin synthase, is overexpressed in colorectal ca ncers and is involved in angiogenesis as well as in tumorigenesis. Zn this study, we investigate the expression of Cox-2 in retinoblastoma, METHODS: T wenty-nine formalin-fixed retinoblastoma specimens were examined by the lab eled-streptavidin-biotin method using anti-Cox-2 antibody. RESULTS: Cox-2 p ositive immunoreactions were observed in 28 (96%) of 29 retinoblastomas spe cimens. CONCLUSION: This preliminary study suggests the overexpression of C ox-2 in both differentiated and undifferentiated retinoblastoma and its pos sible role in tumorigenesis. (C) 2000 by Elsevier Science Inc. All rights r eserved.