A physiological model to predict xenobiotic concentration in fish

A physiological model was developed to estimate fish body toxicant load bas ed on information regarding the chemical exposure regime, fish body weight, lipid content and oxygen uptake. The general model was tested in which an oxygen database (OXYREF) was used to predict fish toxicant body burden. Bas ed on the quantitative analysis, it was shown that the model was reliable a nd accurate in estimating fish body burden of a number of non-metabolized a quatic toxicants. This modified model possesses some functional reality whi ch enables more realistic predictions, making it useful in the practice of aquatic environmental risk assessment. (C) 2000 Elsevier Science B.V. All r ights reserved.