Fits, pyridoxine, and hyperprolinaemia type II

The rare inherited disorder hyperprolinaemia type II presents with fits in childhood, usually precipitated by infection. A diagnosis of hyperprolinaem ia type II and vitamin B-6 deficiency was made in a well nourished child wi th fits. It is thought that pyridoxine deficiency was implicated in her fit s and was the result of inactivation of the vitamin by the proline metaboli te, pyrroline-5-carboxylate.