T. Nakamura et al., A randomised control study of partial liquid ventilation after airway lavage with exogenous surfactant in a meconium aspiration syndrome animal model, ARCH DIS CH, 82(2), 2000, pp. F160-F162
Aims-To test the hypothesis that lavage with exogenous surfactant before pa
rtial liquid ventilation in meconium aspiration syndrome (MAS) would improv
e debris removal, and therefore the effectiveness of partial liquid ventila
tion.
Methods-12 newborn piglets were randomised into 4 groups, partial liquid ve
ntilation or gas ventilation, with and without surfactant lavage. Physiolog
ical and blood gas data were compared between groups by analysis of varianc
e.
Results-Arterial oxygen pressure (PaO2) was improved in the group treated w
ith surfactant lavage when compared with the group not receiving surfactant
. PaO2 in the group receiving surfactant lavage followed by partial liquid
ventilation was further improved when compared with the group treated with
surfactant lavage followed by gas ventilation and the group receiving parti
al Liquid ventilation alone.
Conclusion-The effectiveness of partial liquid ventilation in MAS might be
enhanced by pretreatment with exogenous surfactant bronchial lavage.