The non-enumerable described retrovirus integrase inhibitors are not a lure, as evidenced by ten years of clinical experience

Two retrovirus integrase inhibitors have been discovered on the c-erb proto -oncogene test in 1989, acriflavine and hydroxymethylellipticine. A ten-yea r follow-up of their applications to individual treatments of AIDS patients has provided evidence of their HIV-1 (even AZT-resistant) virostatic effic acy, as of their possible clinical use without toxicity. Hundreds of HIV-1 integrase inhibitors have recently been discovered with an in vitro test. T he clinical effect of vitamin B12, which belongs to them, has already been observed in patients with one-year follow-up. A positive coordination of re turn to this Eden of HN-I AIDS complex pharmacology must be organized at th e highest scientific, and not at the politico-administrative level. (C) 200 0 Editions scientifiques et medicales Elsevier SAS.