Amplifing effect of dietary taurine on the induction of cytochrome P-450 and on the urinary excretion of ascorbic acid in rats fed on phenobarbital-containing diets

Authors
Mochizuki, H Takido, J Oda, H Yokogoshi, H
Citation
H. Mochizuki et al., Amplifing effect of dietary taurine on the induction of cytochrome P-450 and on the urinary excretion of ascorbic acid in rats fed on phenobarbital-containing diets, BIOS BIOT B, 64(2), 2000, pp. 405-407
Citations number
18
Categorie Soggetti
Agricultural Chemistry","Biochemistry & Biophysics
Journal title
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
ISSN journal
09168451 → ACNP
Volume
64
Issue
2
Year of publication
2000
Pages
405 - 407
Database
ISI
SICI code
0916-8451(200002)64:2<405:AEODTO>2.0.ZU;2-E
Abstract
Dietary taurine amplified the induction of cytochrome P-450 and the urinary excretion of ascorbic acid in rats fed on phenobarbital (PB)-containing di ets. These facts suggest that taurine could influence the hepatic metabolis m of xenobiotics via the induction of drug-metabolizing enzymes (DME) and t he ascorbic acid metabolism. Taurine might improve the function of DME expo sed by some xenobiotics.