Constrictive pericarditis post allogeneic bone marrow transplant for Philadelphia-positive acute lymphoblastic leukaemia

Citation
J. Cavet et al., Constrictive pericarditis post allogeneic bone marrow transplant for Philadelphia-positive acute lymphoblastic leukaemia, BONE MAR TR, 25(5), 2000, pp. 571-573
Citations number
12
Categorie Soggetti
Hematology,"Medical Research Diagnosis & Treatment
Journal title
BONE MARROW TRANSPLANTATION
ISSN journal
02683369 → ACNP
Volume
25
Issue
5
Year of publication
2000
Pages
571 - 573
Database
ISI
SICI code
0268-3369(200003)25:5<571:CPPABM>2.0.ZU;2-D
Abstract
We describe two cases of severe constrictive pericarditis arising after all ogeneic BMT conditioning involving total body irradiation and melphalan to treat Philadelphia-chromosome positive ALL, Both patients required pericard ectomy, resulting in marked improvement in ventricular filling. However, a degree of right-sided cardiac failure persisted in both patients secondary to restrictive cardiomyopathy, Constrictive pericarditis has not been previ ously described after BMT, but has been observed following thoracic radioth erapy for malignancy, usually involving a substantially higher radiation do se. Pericardial constriction and restrictive cardiomyopathy should be consi dered as causes of breathlessness and/or oedema occurring late after BMT.