J. Cavet et al., Constrictive pericarditis post allogeneic bone marrow transplant for Philadelphia-positive acute lymphoblastic leukaemia, BONE MAR TR, 25(5), 2000, pp. 571-573
Citations number
12
Categorie Soggetti
Hematology,"Medical Research Diagnosis & Treatment
We describe two cases of severe constrictive pericarditis arising after all
ogeneic BMT conditioning involving total body irradiation and melphalan to
treat Philadelphia-chromosome positive ALL, Both patients required pericard
ectomy, resulting in marked improvement in ventricular filling. However, a
degree of right-sided cardiac failure persisted in both patients secondary
to restrictive cardiomyopathy, Constrictive pericarditis has not been previ
ously described after BMT, but has been observed following thoracic radioth
erapy for malignancy, usually involving a substantially higher radiation do
se. Pericardial constriction and restrictive cardiomyopathy should be consi
dered as causes of breathlessness and/or oedema occurring late after BMT.