Trisomy 15, sex chromosome loss, and hematological malignancy

We report 6 patients with myelodysplasia who, on routine cytogenetic studie s, demonstrated trisomy 15. Four of these also had sex chromosome loss, A r eview of the literature revealed 6 other cases of trisomy 15 with sex chrom osome loss and 22 cases of trisomy 15 as the sole chromosomal abnormality. All cases had hematologic malignancy or myelodysplasia. Trisomy 15 is uncom mon but tends to be associated with myelodysplasia in older subjects, and w ith sex chromosome loss in about one third of cases. (C) Elsevier Science I nc., 2000. All rights reserved.