Km. Hyun et al., STABILIZATION OF POLY(DA)CENTER-DOT[POLY(DT)](2) TRIPLE-HELICAL DNA BY ACRIDINE-DERIVATIVES - ROLE OF SIDE-CHAIN IN THE TRIPLEX STABILIZATION, Bulletin of the Korean Chemical Society, 18(5), 1997, pp. 528-534
The conformation and stabilization effects of acridine derivatives 9-a
minoacridine, an acridine with an aminoalkyl side chain, bis acridine
(two acridines linked by an aminoalkyl side chain), and proflavin in t
he tripler helical poly(dA).[poly(dT)](2) were investigated by optical
spectroscopies. Based on the negative LD and weak positive CD in the
acridine absorption wavelength region, we concluded that the acridine
moiety of all derivatives are intercalated. We also examined the melti
ng temperatures. Of all the compounds examined, the acridine with an a
mino alkyl side chain had the strongest effect on the stabilization of
the third strand of a poly (dA).[poly(dT)](2) tripler. The role of th
e side chain, based on this observation, is discussed.