The role of SLP-76 and LAT in lymphocyte development

Authors
Pivniouk, VI Geha, RS
Citation
Vi. Pivniouk et Rs. Geha, The role of SLP-76 and LAT in lymphocyte development, CURR OP IM, 12(2), 2000, pp. 173-178
Citations number
72
Categorie Soggetti
Immunology
Journal title
CURRENT OPINION IN IMMUNOLOGY
ISSN journal
09527915 → ACNP
Volume
12
Issue
2
Year of publication
2000
Pages
173 - 178
Database
ISI
SICI code
0952-7915(200004)12:2<173:TROSAL>2.0.ZU;2-M
Abstract
SLP-76 and LAT are two recently identified adapter proteins that are involv ed in the signal transduction cascade initiated by engagement of the TCR. T he role of these two molecules in thymocyte development has become clearer following studies of gene targeted mice. The data indicate that SLP-76 and LAT are each critical for the expansion and differentiation of double-negat ive thymocytes and that SLP-76 is essential for allelic exclusion at the TC R beta locus.