In-vivo and in-vitro nutrient-gene interactions

Association studies of gene variants and response to dietary challenges rep resent one way of investigating gene-nutrient interactions. Several studies reported in the present review concentrate on evaluating variation at the apolipoprotein AI-CII-AIV and apolipoprotein E gene loci, as well as the fa tty acid binding protein gene. In addition, the effect of nutrients can be directly evaluated at the level of gene expression, and reports of in-vitro studies of control of fatty acid and triglycerides synthesis are discussed in the present review. Curr Opin Lipidoli 11:31-36. (C) 2000 Lippincott Wi lliams & Wilkins.