THE HYDROGENATION AND DEUTERATION OF ESTRONE

Authors
WAHALA K KIURU P KALTIA S KOSKIMIES J HASE T
Citation
K. Wahala et al., THE HYDROGENATION AND DEUTERATION OF ESTRONE, Synlett, (5), 1997, pp. 460
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
5
Year of publication
1997
Database
ISI
SICI code
0936-5214(1997):5<460:THADOE>2.0.ZU;2-9
Abstract
Hydrogenation (H-2/PdC) of estrone (1) gives estrane-3,17-dione (2), t he 5 alpha,10 alpha A/B ring fusion stereochemistry being established by NMR. Reduction of estrone using D-2/PdC gives 1 alpha,2 alpha,4 alp ha,5 alpha 6,6,9 alpha 10 alpha-d(8)-estrane-3,17-dione (3).