ASYMMETRIC HYDROGENATION OF CYCLIC ALPHA,BETA-UNSATURATED KETONES TO CHIRAL ALLYLIC ALCOHOLS

Authors
OHKUMA T IKEHIRA H IKARIYA T NOYORI R
Citation
T. Ohkuma et al., ASYMMETRIC HYDROGENATION OF CYCLIC ALPHA,BETA-UNSATURATED KETONES TO CHIRAL ALLYLIC ALCOHOLS, Synlett, (5), 1997, pp. 467
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
5
Year of publication
1997
Database
ISI
SICI code
0936-5214(1997):5<467:AHOCAK>2.0.ZU;2-6
Abstract
The Ru(II)-BINAP-1,2-diphenylethylenediamine combined catalyst system effects asymmetric hydrogenation of certain cyclic enones in 2-propano l containing KOH with a substrate/catalyst molar ratio of 250 to 2500. The hydrogenation occurs selectively at the C=O function with excelle nt enantio- or diastereoselectivity.