FACILE SYNTHESIS OF ALPHA-KETO ESTERS VIA A FREE-RADICAL ACYLATION APPROACH

Authors
KIM S YOON JY LEE IY
Citation
S. Kim et al., FACILE SYNTHESIS OF ALPHA-KETO ESTERS VIA A FREE-RADICAL ACYLATION APPROACH, Synlett, (5), 1997, pp. 475
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
5
Year of publication
1997
Database
ISI
SICI code
0936-5214(1997):5<475:FSOAEV>2.0.ZU;2-A
Abstract
A new efficient method for the preparation of alpha-keto esters via a free radical acylation approach using phenylsulfonyl methoxycarbonyl o xime ether 1 has been developed. When an alkyl iodide was treated with 1, hexamethylditin, and acetone in THF at 300 nm for 3 h, alpha-keto ester 3 was obtained in high yield after hydrolysis of the oxime ether 2.