ENANTIOSELECTIVE ALKYLATION OF ALDEHYDES WITH DIETHYLZINC CATALYZED BY C-2-SYMMETRICAL LIGANDS

Authors
WILLIAMS DR FROMHOLD MG
Citation
Dr. Williams et Mg. Fromhold, ENANTIOSELECTIVE ALKYLATION OF ALDEHYDES WITH DIETHYLZINC CATALYZED BY C-2-SYMMETRICAL LIGANDS, Synlett, (5), 1997, pp. 523
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
5
Year of publication
1997
Database
ISI
SICI code
0936-5214(1997):5<523:EAOAWD>2.0.ZU;2-6
Abstract
The C-2-symmetric pyridine 1, incorporating two units of (-)-ephedrine , is an effective catalyst for the enantioselective reactions of dieth ylzinc with a series of aromatic aldehydes. The propanol products poss ess the S-configuration. This result is a significant reversal of ster eochemistry based upon literature precedents and our direct comparison s with reactions catalyzed by the corresponding C-2-symmetric xylene 2 .