Molecular cloning of MINK, a novel member of mammalian GCK family kinases,which is up-regulated during postnatal mouse cerebral development

Authors
Dan, I Watanabe, NM Kobayashi, T Yamashita-Suzuki, K Fukagaya, Y Kajikawa, E Kimura, WK Nakashima, TM Matsumoto, K Ninomiya-Tsuji, J Kusumi, A
Citation
I. Dan et al., Molecular cloning of MINK, a novel member of mammalian GCK family kinases,which is up-regulated during postnatal mouse cerebral development, FEBS LETTER, 469(1), 2000, pp. 19-23
Citations number
23
Categorie Soggetti
Biochemistry & Biophysics
Journal title
FEBS LETTERS
ISSN journal
00145793 → ACNP
Volume
469
Issue
1
Year of publication
2000
Pages
19 - 23
Database
ISI
SICI code
0014-5793(20000303)469:1<19:MCOMAN>2.0.ZU;2-M
Abstract
A new germinal center kinase (GCK) family kinase, Misshapen/NIKs-related ki nase (MINK), has been cloned and its expression has been characterized in s everal tissues and various developmental stages of the mouse brain. MINK en codes a 1300 amino acid polypeptide, consisting of an N-terminal kinase dom ain, a proline-rich intermediate region, and a C-terminal GCK homology regi on. The expression of MINK is up-regulated during the postnatal development of the mouse brain. MINK activates the cJun N-terminal kinase and the p38 pathways. (C) 2000 Federation of European Biochemical Societies.