A transcript map of a 10-Mb region of chromosome 19: A source of genes forhuman disorders, including candidates for genes involved in asthma, heart defects, and eye development

Several projects have produced maps of the physical position of genes withi n the human genome, either on a genome-wide scale or of a more detailed sub section of a chromosome. However, these maps largely rely on the mapping of expressed sequences (cDNAs and ESTs) back onto physical maps by their loca lization onto specific fragments of DNA within the radiation hybrid panels. In this report we present a gene map of a section of chromosome 19 that ha s been derived by combining the use of a method of gene identification (exo n trapping) that does not rely on expression patterns, with data available in the genome databases to produce a fine-detailed transcript map. This map also provides several potential candidates for disorders that map to this region of the genome. Details of the maps and more detailed descriptions of cosmid contigs, exon sequences, and expression patterns for the 96 exons t hat form the basis of this transcript map are available on a series of Web pages that are referenced in this report. These Web pages can be accessed f rom http://www.nottingham.ac.uk/similar to pdzmgh/tm/livemap19q. html. (C) 2000 Academic Press.