Ovarian cancer in female-to-male transsexuals: Report of two cases

Background. Ovarium cancer is the fifth most common cause of cancer-related death in women and is the most common fatal gynecologic malignancy. So far , ovarium carcinoma has not been reported to have occurred in female-to-mal e transsexuals. Objective and method. We report on two such cases. Long-term exposure to in creased levels of endogenous and exogenous androgens is hypothesized to con stitute an additional risk factor in transsexuals as it has been associated with ovarian epithelian cancer. Conclusion. Simultaneous salpingo-oophorectomy should be performed in any f emale-to-male transsexual undergoing hysterectomy in the course of gender-c onfirming therapy. (C) 2000 Academic Press.