Frequency of Gilbert's syndrome associated with UGTA1 (TA)(7) polymorphismin Southern Italy

Authors
Iolascon, A Perrotta, S Coppola, B Carbone, R del Giudice, EM
Citation
A. Iolascon et al., Frequency of Gilbert's syndrome associated with UGTA1 (TA)(7) polymorphismin Southern Italy, HAEMATOLOG, 85(3), 2000, pp. 335-336
Citations number
10
Categorie Soggetti
Cardiovascular & Hematology Research
Journal title
HAEMATOLOGICA
ISSN journal
03906078 → ACNP
Volume
85
Issue
3
Year of publication
2000
Pages
335 - 336
Database
ISI
SICI code
0390-6078(200003)85:3<335:FOGSAW>2.0.ZU;2-H
Abstract
We screened 685 subjects from Southern Italy for a promoter polymorphism of the UDP-glucuronosyltransferase (UGTA1) gene tightly linked to Gilbert's s yndrome (CS), consisting in the insertion of a TA repeat in the TATA box. T he frequency of the polymorphism was 0.387 which is similar to the frequenc ies reported for other investigated populations of different ethnic backgro unds and is consistent with the antiquity of this polymorphism.