Gm. Ignatiev et al., Immune and pathophysiological processes in baboons experimentally infectedwith Ebola virus adapted to guinea pigs, IMMUNOL LET, 71(2), 2000, pp. 131-140
The dynamics of pathophysiological and immunological parameters monitored i
n monkeys Papio hamadryas infected with the guinea pig-adapted Ebola virus
strain demonstrated that this viral strain preserved its virulence for monk
eys and caused the disease with characteristic features similar to those ca
used by non-adapted Ebola virus. However, certain previously unknown patter
ns have been observed: (1) prolongation of the febrile period by two days;
(2) extended period was characterized by stability of serum biochemical par
ameters; (3) marked vacuolization of the neutrophil cytoplasm; (4) appearan
ce of juvenile lymphocytes on day 3 and by the end of the disease; and (5)
a considerable increase in the spontaneous mononuclear proliferation (along
with a decrease in the mitogen-induced proliferation) during the terminal
stage of infection. The severity of pathological coagulation was found to c
orrelate with the activity of serum cytokines - IFN-alpha and TNF-alpha: th
eir activities increased about 250- and 100-fold, respectively. There was s
ignificant alteration in the activity of natural killer cells, that dropped
by the time of animal death. (C) 2000 Elsevier Science B.V. All rights res
erved.