Molecular mimicry by cytomegaloviruses - Function of cytomegalovirus-encoded homologues of G protein-coupled receptors, MHC class I heavy chains and chemokines

Cytomegaloviruses (CMVs) are well known for their high prevalence rate with in host populations as well as their ability to induce lifelong infections. To maintain a persistent and stable relationship with their host, CMVs hav e evolved various molecular mechanisms to both control host cell metabolism and evade immune surveillance. Among the viral gene products that are like ly to be involved in these processes are homologues of cellular G protein-c oupled receptors, MHC class I molecules and chemokines. The viral genes enc oding these homologues have probably been pirated by the viruses during a l ong pathogen/host coevolution, In this report, we will discuss the possible functions of these homologues in the pathogenesis of CMV infections. Copyr ight (C) 2000 S. Karger AG, Basel.