Regional ventilation-perfusion distribution is more uniform in the prone position

The arterial blood PO2 is increased in the prone position in animals and hu mans because of an improvement in ventilation ((V) over dot A) and perfusio n ((Q) over dot) matching. However, the mechanism of improved (V) over dot A/(Q) over dot is unknown. This experiment measured regional (V) over dot A /(Q) over dot heterogeneity and the correlation between (V) over dot A and (Q) over dot in supine and prone positions in pigs. Eight ketamine diazepam -anesthetized, mechanically ventilated pigs were studied in supine and pron e positions in random order. Regional (V) over dot A and (Q) over dot were measured using fluorescent-labeled aerosols and radioactive-labeled microsp heres, respectively. The lungs were dried at total lung capacity and cubed into 603-967 small (similar to 1.7-cm(3)) pieces. In the prone position the homogeneity of the ventilation distribution increased (P = 0.030) and the correlation between (V) over dot A and (Q) over dot increased (correlation coefficient = 0.72 +/- 0.08 and 0.82 +/- 0.06 in supine and prone positions , respectively, P = 0.03). The homogeneity of the (V) over dot A/(Q) over d ot distribution increased in the prone position (P = 0.028). We conclude th at the improvement in (V) over dot A/(Q) over dot matching in the prone pos ition is secondary to increased homogeneity of the (V) over dot A distribut ion and increased correlation of regional (V) over dot A and (Q) over dot.