Noninvasive functional imaging of human brain using light

Citation
Da. Benaron et al., Noninvasive functional imaging of human brain using light, J CEREBR B, 20(3), 2000, pp. 469-477
Citations number
74
Categorie Soggetti
Neurosciences & Behavoir
Journal title
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
ISSN journal
0271678X → ACNP
Volume
20
Issue
3
Year of publication
2000
Pages
469 - 477
Database
ISI
SICI code
0271-678X(200003)20:3<469:NFIOHB>2.0.ZU;2-4
Abstract
Analysis of photon transit time for low-power fight passing into the head, and through both skull and brain, of human subjects allowed for tomographic imaging of cerebral hemoglobin oxygenation based on photon diffusion theor y; In healthy adults, imaging of changes in hemoglobin saturation during ha nd movement revealed focal, contralateral increases in motor cortex oxygena tion with spatial agreement to activation maps determined by functional mag netic resonance imaging; in ill neonates, imaging of hemoglobin saturation revealed focal regions of low oxygenation after acute stroke, with spatial overlap to injury location determined by computed tomography scan. Because such slow optical changes occur over seconds and co-localize with magnetic resonance imaging vascular signals whereas fast activation-related optical changes occur over milliseconds and co-localize with EEG electrical signals , optical methods offer a single modality for exploring the spatiotemporal relationship between electrical and vascular responses in the brain in vivo , as well as for mapping cortical activation and oxygenation at the bedside in real-time for clinical monitoring.